Decreased level of endogenous secretory receptor for advanced glycation end-products in diabetes with concomitant hyperlipidemia

Title:

Decreased level of endogenous secretory receptor for advanced glycation end-products in diabetes with concomitant hyperlipidemia

Creator:

Turk, Z., Ljubić, S., and Boras, J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:7218d700-1942-49b6-bd6f-f02eade886c1
uuid:7218d700-1942-49b6-bd6f-f02eade886c1

Subject:

Fyziologie člověka a srovnávací fyziologie, hyperlipidémie, hyperlipidemia, advanced glycation pathway, type 2 diabetes, endogenous secretory receptor for AGE, AGE-to-esRAGE ratio, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Endogenous secretory receptor (esRAGE) for advanced glycation end-product (AGE) acts as decoy for AGEs. The AGE-to-esRAGE ratio was hypothesized to be implicated in diabetic vasculopathy. We investigated an associatio n of esRAGE and methylglyoxal- adducts serum level, as well as AGE-to-esRAGE ratio in subpopulation of diabetic patients with or without concomitant hyperlipidemia and macrovascular disease in history. In diabetes with concomitant hyperlipidemia esRAGE was significantly decreased compared to hyperlipidemia with normal glucose metabolism (0.306±0.2 vs. 0.367± 0.1; p=0.019) or diabetes alone (0.306±0.2 vs. 0.404±0.1; p = 0.004). High AGE/esRAGE ratio, found in diabetic patients with hyperlipidemia, pointed to increased production of AGEs and low expression of esRAGE. In multivariable analysis adjusted for several confounding factors, increased AGE/esRAGE ratio was re cognized as a high risk for vascular disease outcomes., Z. Turk, S. Ljubić, J. Boras., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:2

Harvested from:

CDK

Metadata only:

false