The protective influence of selenium on oxidant disturbances in brain of rats exposed to lithium

Title:

The protective influence of selenium on oxidant disturbances in brain of rats exposed to lithium

Creator:

Kiełczykowska, M., Kocot, J., Lewandowska, A., Żelazowska, R., and Musik, I.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:6e6e71fb-1543-4f32-9ade-bc8735cb0e80
uuid:6e6e71fb-1543-4f32-9ade-bc8735cb0e80
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, selen, lithium, oxidační stres, mozek, selenium, oxidative stress, brain, rats, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

For more than sixty years lith ium carbonate has been used in medicine. However, during its administration different side effects including oxidative stress can occur. Selenium belongs to essential elements possessing antioxidant properties. This study aimed at evaluating if selenium co uld be used as a protective adjuvant in lithium therapy. The experiment was performed on four groups of Wistar rats: I (control), II (Li), III (Se), IV (Li + Se) treated with saline, lithium carbonate (2.7 mg Li/kg b.w.), sodium selenite (0.5 mg Se/kg b.w.) and lithium carbonate (2.7 mg Li/kg b.w.) + sodium selenite (0.5 mg Se/kg b.w.), respectively. All substances were administered as water solutions by stomach tube for 3 or 6 weeks. Catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GP x) as well as malonyldialdehyde (MDA) were determined in brain homogenates. Lithium slightly enhanced MDA and depressed CAT and SOD after 6 weeks as well as GPx after 3 weeks. Selenium co -administration show ed tendency to restore the disturbed parameters. Selenium alone and given with lithium significantly increased GPx vs. Li- treated group after 3 weeks. Having regarded the outcomes of this study, the research on application of selenium during lithium treatment seems to be worth continuation., M. Kiełczykowska, J. Kocot, A. Lewandowska, R. Żelazowska, I. Musik., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:5

Harvested from:

CDK

Metadata only:

false