Biomarkers of oxidative stress and endothelial dysfunction after tourniquet release in children

Title:

Biomarkers of oxidative stress and endothelial dysfunction after tourniquet release in children

Creator:

Budic, I., Pavlovic, D., Kocic, G., Cvetkovic, T., Simic, D., Basic, J., and Zivanovic, D.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:6b2cd964-ecb1-45e5-8a71-be8618b6ab8f
uuid:6b2cd964-ecb1-45e5-8a71-be8618b6ab8f

Subject:

Fyziologie člověka a srovnávací fyziologie, oxidační stres, endotel, oxidative stress, endothelium, tourniquet, child, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Pneumatic tourniquets are widely used in pediatric extremity surgery to provide a bloodless field and facilitate dissection. This prospective study was carried out to examine possible effect of different anesthesia techniques on oxidative stress and endothelial dysfunction connected with ischemia-reperfusion injury during extremity operations at children's age. Patients were randomized into three groups of 15 patients each: general inhalational anesthesia with sevoflurane (group S), total intravenous anesthesia with propofol (group T) and regional anesthesia (group R). Venous blood samples for determination of the malondialdehyde in plasma and erythrocytes, protein carbonyl groups concentration as well as plasma nitrites and nitrates level and xanthine oxidase activity were obtained at four time points: be fore peripheral nerve block and induction of general anesthesia (baseline), 1 min before tourniquet release, 5 and 20 min after tourniquet release. This study demonstrates that total intravenous anesthesia with propofol and regional anesthesia techniques provide better antioxidant defense and reduce endothelial dysfunct ion than general inhalational anesthesia with sevoflurane during tourniquet application in pediatric extremity surgery., I. Budic ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false