Red palm oil supplementation does not increase blood glucose or serum lipids levels in Wistar rats with different thyroid status

Title:

Red palm oil supplementation does not increase blood glucose or serum lipids levels in Wistar rats with different thyroid status

Creator:

Hana Rauchová, Martina Vokurková, Tomáš Soukup, Narcisa Tribulová, Vaněčková, I, and Stanislav Pavelka

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:655627c1-a413-4e54-a45a-45def14e9be7
uuid:655627c1-a413-4e54-a45a-45def14e9be7
issn:0862-8408

Subject:

fyziologie člověka, human physiology, Hypothyroidism, Hyperthyroidism, Heart, Cholesterol, Glutathione, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

Red palm oil (RPO) is a rich natural source of antioxidant vitamins, namely carotenes, tocopherols and tocotrienols. However, it contains approximately 50 % saturated fatty acids the regular consumption of which could negatively modify lipid profile. The aim of our study was to test whether 7 weeks of RPO supplementation (1 g/kg body weight/day) would affect blood glucose and lipid metabolism in adult male Wistar rats with altered thyroid status. We induced hypothyroidism and hyperthyroidism in rats by oral administration of either methimazole or mixture of thyroid hormones. Different thyroid status (EU - euthyroid, HY - hypothyroid and HT - hyperthyroid) was characterized by different serum thyroid hormones levels (total and free thyroxine and triiodothyronine), changes in the activity of a marker enzyme of thyroid status - liver mitochondrial glycerol-3-phosphate dehydrogenase, and altered absolute and relative heart weights. Fasting blood glucose levels were higher in HT rats in comparison with EU and HY rats, but the changes caused by RPO supplementation were not significant. The achievement of the HY status significantly increased serum levels of total cholesterol, as well as with high-density lipoproteincholesterol and low-density lipoprotein-cholesterol: 2.43±0.15, 1.48±0.09, 0.89±0.08 mmol/l, compared to EU: 1.14±0.06, 0.77±0.06, 0.34±0.05 mmol/l and HT: 1.01±0.06, 0.69±0.04, 0.20±0.03 mmol/l, respectively. RPO supplementation did not increase significantly levels of blood lipids but tended to increase glutathione levels in the liver. In conclusion, RPO supplementation did not induce the presumed deterioration of glucose and lipid metabolism in rats with three well-characterized alterations in thyroid status., H. Rauchová, M. Vokurková, S. Pavelka, I. Vaněčková, N. Tribulová, T. Soukup., and Seznam literatury

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:2

Harvested from:

CDK

Metadata only:

false