Changes of hippocampal noradrenergic capacity in stress condition

Title:

Changes of hippocampal noradrenergic capacity in stress condition

Creator:

Gavrilović, L., Popović, N., Stojiljković, V., Pejić, S., Todorović, A., Pavlović, I., and Pajović, S. B.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:578ae9d4-9083-4bb3-8081-7d0264b8e0d6
uuid:578ae9d4-9083-4bb3-8081-7d0264b8e0d6

Subject:

chronic restraint stress, noradrenaline, hippocampus, and rats

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

This study aimed to investigate the effects of chronic restraint stress (CRS) on the protein levels of dopamine-β-hydroxylase (DBH), noradrenaline transporter (NET), vesicular monoamine transporter 2 (VMAT2) and brain-derived neurotrophic factor (BDNF), as well as the concentration of noradrenaline (NA) in the rat hippocampus. The investigated parameters were quantified by Western blot analyses and ELISA kits. We found that CRS increased the protein levels of DBH by 30 %, VMAT2 by 11 %, BDNF by 11 % and the concentration of NA by 104 %, but decreased the protein levels of NET by 16 % in the hippocampus of chronically stressed rats. The molecular mechanisms by which CRS increased the hippocampal NA level are an important adaptive phenomenon of the noradrenergic system in the stress condition.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

81-84

Source:

Folia biologica | 2020 Volume:66 | Number:2

Harvested from:

CDK

Metadata only:

false