The comparison of antioxidant and hematological properties of N-acetylcysteine and α-lipoic acid in physically active males

Title:

The comparison of antioxidant and hematological properties of N-acetylcysteine and α-lipoic acid in physically active males

Creator:

Zembron-Lacny, A., Slowinska-Lisowska, M., Szygula, Z., Witkowski, K., and Szyszka, K.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:54296625-b6fb-424d-a241-ad629957b04e
uuid:54296625-b6fb-424d-a241-ad629957b04e

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, thioly, antioxidanty, physiology, thiols, antioxidants, oxidační poškození, erythropoietin, oxidative damage, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

The aim of this study was to follow up whether the modification of pro-antioxidant status by oral thiol administration such as N- acetylcysteine and α-lipoic acid affects the hematological response. Twenty-eight healthy men participated in two independent experiments. Subjects were randomly assigned to one of four groups: controls (CNAC and CALA ), N-acetylcysteine (NAC) and α-lipoic acid (ALA). 1200 mg of N-acetylcysteine, 600 mg of α-lipoic acid or placebo were administered for 8 days in two doses. NAC or ALA administration significantly elevated plasma total antioxidant stat us (TAS) and reduced protein carbonylation (PC) and lipid peroxidation (TBARS) by more than 30 %. The reduced glutathione (GSH) and hematological parameters changed only in response to NAC administration. NAC significantly elevated the level of GSH (+33 %), EPO (+26 %), Hb (+9 %) and Hct (+9 %) compared with CNAC. The mean corpuscular volume (MCV) and the mean corpuscular hemoglobin (MCH) also increased by more than 12 % after NAC. The numerous negative or positive correlations between the measures of TAS, PC, TBARS and hematological parameters were found, which suggest the NAC-induced interaction between pro-antioxidant and hematological values. Our study has shown that both N-acetylcysteine and α-lipoic acid intake reveal an antioxidant action, but only N-acetylcysteine improves the haematological response., A. Zembron-Lacny ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:6

Harvested from:

CDK

Metadata only:

false