Lipoprotein lipase activity determined in vivo is lower in carries of apolipoprotein A-V gene variants 19W and -1131C

Title:

Lipoprotein lipase activity determined in vivo is lower in carries of apolipoprotein A-V gene variants 19W and -1131C

Creator:

Jan Kovář and Věra Adámková

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:53eb1516-7c7b-476c-99dc-3a5eb9412736
uuid:53eb1516-7c7b-476c-99dc-3a5eb9412736
issn:0862-8408

Subject:

Buněčná biologie. Cytologie, fyziologie, genetika, lipoproteiny, mastné kyseliny, physiology, genetics, lipoproteins, fatty acids, apolipoprotein A-V, lipoprotein lipase, nonesterified fatty acids, 2, and 576

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The apolipoprotein A-V (apo A-V) plays an important role in regulation of triglyceride (TG) concentration in serum. To better understand how apo A-V affects triglyceridemia and glucoregulation, the lipoprotein lipase (LPL) activity was determined using intravenous fat tolerance test (IVFTT) and oral glucose tolerance test (oGTT) was performed in carriers of apolipoprotein A-V gene ( APOAV) variants known to be associated with increased triglyceridemia. Twelve carriers of 19W variant, 16 carriers of -1131C variant, 1 combined heterozygote and 16 control subjects homozygous for wild type variants (19S/-1131T) were selected from a population sample and matched with respect to body mass index and age. The APOAV variants carriers had increased TG, very low density lipoprotein-TG, and apo B concentrations (p < 0.05). The LPL activity evaluated as k2 rate constant for clearance of Intralipid® was 14 % lower in APOAV variants carriers. The depression of nonesterified fatty acids (NEFA) concentration after glucose load was delayed in APOAV variants carriers in spite of the same insulinemia and glycemia. Our results suggest that variants of APOAV combined with increased triglyceridemia are associated with lower LPL activity in vivo and with disturbances of regulation of NEFA concentration after glucose load., J. Kovář, V. Adámková., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:4

Harvested from:

CDK

Metadata only:

false