Composition of Plasma Fatty Acids and Non-Cholesterol Sterols in Anorexia Nervosa

Title:

Composition of Plasma Fatty Acids and Non-Cholesterol Sterols in Anorexia Nervosa

Creator:

Žák, A., Vecka, M., Tvrzická, E., Hrubý, M., Novák, F., Papežová, H., Lubanda, H., Veselá, L., and Staňková, B.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:51988c8c-1023-46b7-b0c2-561980865012
uuid:51988c8c-1023-46b7-b0c2-561980865012

Subject:

Anorexia, Plasma lipids, Lipoproteins, Lathosterol, Fatty acids, and Plants sterols

Type:

article, model:article, and TEXT

Description:

Anorexia nervosa is a model of simple starvation accompanied by secondary hyperlipoproteinemia. The pattern of plasma fatty acids influences the levels of plasma lipids and lipoproteins. The concentration of plasma lathosterol is a surrogate marker of cholesterol synthesis de novo, concentrations of campesterol and beta-sitosterol reflect resorption of exogenous cholesterol. The aim of the study was to evaluate fatty acids in plasma lipid classes and their relationship to plasma lipids, lipoproteins, cholesterol precursors and plant sterols. We examined 16 women with anorexia nervosa and 25 healthy ones. Patients with anorexia nervosa revealed increased concentrations of total cholesterol, triglycerides, HDL-cholesterol, campesterol and beta-sitosterol. Moreover, a decreased content of n-6 polyunsaturated fatty acids was found in all lipid classes. These changes were compensated by an increased content of monounsaturated fatty acids in cholesteryl esters, saturated fatty acids in triglycerides and both monounsaturated and saturated fatty acids in phosphatidylcholine. The most consistent finding in the fatty acid pattern concerned a decreased content of linoleic acid and a raised content of palmitoleic acid in all lipid classes. The changes of plasma lipids and lipoproteins in anorexia nervosa are the result of complex mechanisms including decreased catabolism of triglyceride-rich lipoproteins, normal rate of cholesterol synthesis and increased resorption of exogenous cholesterol.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2005 Volume:54 | Number:4

Harvested from:

CDK

Metadata only:

false