Baroreflex sensitivity in children and adolescents: physiology, hypertension, obesity, diabetes mellitus

Title:

Baroreflex sensitivity in children and adolescents: physiology, hypertension, obesity, diabetes mellitus

Creator:

Honzíková, N. and Závodná, E.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:516a2feb-24e3-41c2-9c13-0c9d36de510e
uuid:516a2feb-24e3-41c2-9c13-0c9d36de510e

Subject:

baroreflex sensitivity, adolescents, Hypertension, Obesity, and Diabetes mellitus

Type:

article, model:article, and TEXT

Description:

The increased prevalence of obesity in children and its complications have led to a greater interest in studying baroreflex sensitivity (BRS) in children. This review of BRS in children and adolescents includes subtopics on: 1. Resting values of BRS and their reproducibility, 2. Genetics of BRS, 3. The role of a primarily low BRS and obesity in the development of hypertension, and 4. Association of diabetes mellitus, BRS, and obesity. The conclusions specific to this age follow from this review: 1. The mean heart rate (HR) influences the measurement of BRS. Since the mean HR decreases during adolescence, HR should be taken into account. 2. A genetic dependency of BRS was found. 3. Low BRS values may precede pathological blood -pressure elevation in children with white-coat hypertension. We hypothesize that low BRS plays an active role in the emergence of hypertension in youth. A contribution of obesity to the development of hypertension was also found. We hypothesize that both factors, a primarily low BRS and obesity, are partially independent risk factors for hypertension in youths. 4. In diabetics, a low BRS compared to healthy children can be associated with insulin resistance. A reversibility of the BRS values could be possible after weight loss.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2016 Volume:65 | Number:6

Harvested from:

CDK

Metadata only:

false