Effects of pharmacological lesion of adrenergic innervation of the dorsal vagal nucleus on pancreatic insulin secretion in normal and vagotomized rats

Title:

Effects of pharmacological lesion of adrenergic innervation of the dorsal vagal nucleus on pancreatic insulin secretion in normal and vagotomized rats

Creator:

Siaud, P., Mekaouche, M., Givalois, L., Balmefrezol, M., Marcilhac, A., and Ixart, G.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:50c1b652-4771-4495-a065-c74204fb5880
uuid:50c1b652-4771-4495-a065-c74204fb5880

Subject:

dorsal motor nucleus of the vagus nerve, adrenergic innervation, 6-OHDA lesion, pancreatic insulin secretion, vagotomy, and rats

Type:

article, model:article, and TEXT

Description:

Previous morphological and physiological studies have suggested that the adrenergic innervation of the dorsal motor nucleus of the vagus nerve (dmnX) is involved in direct synaptic inhibition of parasympathetic preganglionic neurones of the vagus that control secretion of pancreatic insulin. We investigated the effects of bilateral 6-hydroxydopamine (6-OHDA) lesions of adrenergic innervation of the dmnX on pancreatic insulin secretion and glycaemia in normal and vagotomized rats. After two weeks the 6-OHDA lesions produced a marked increase in circulating insulin levels, but no change in glycaemia. Hyperinsulinaemia after adrenergic denervation of the dmnX was more pronounced when a glucose bolus was injected intraarterially. Bilateral subdiaphragmatic vagotomy reversed the observed hyperinsulinaemia. This targeted pharmacological lesion of the adrenergic innervation of dmnX thus causes hypersecretion by pancreatic B cells, an effect which requires an intact vagus nerve.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1995 Volume:44 | Number:4

Harvested from:

CDK

Metadata only:

false