Endocrine disruptors, obesity, and cytokines: how relevant are they to PCOS?

Title:

Endocrine disruptors, obesity, and cytokines: how relevant are they to PCOS?

Creator:

Šimková, Markéta, Vítků, Jana, Kolátorová Sosvorová, Lucie, Vrbíková, Jana, Vosátková, Michala, Včelák, Josef, and Dušková, Michaela

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:50635973-cfe3-4530-a160-7f3a14c54b7d
uuid:50635973-cfe3-4530-a160-7f3a14c54b7d
issn:0862-8408
doi:10.33549/physiolres.934521

Subject:

obezita, cytokiny, obesity, cytokines, bisphenols, parabens, liquid chromatography-mass spectrometry, 14, and 612

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

As environmental and genetic components contribute to the PCOS expression, we compared levels of endocrine disruptors, steroid hormones, cytokines, and metabolic parameters in twenty healthy, nine normal-weight PCOS women, and ten obese PCOS women. Steroid hormones, bisphenols (BPA, BPS, BPF, BPAF) and parabens (methyl-, ethyl-, propyl-, butyl-, benzyl-parabens) were measured by liquid chromatography-tandem mass spectrometry. Differences between the groups were assessed using the Mann-Whitney U test. Spearman correlation coefficients were calculated for the individual parameters relationship. Significantly higher levels of BPA, anti-Müllerain hormone, lutropine, lutropine/folitropine ratio, testosterone, androstenedione, 7β-OH-epiandrosterone, and cytokines (IL-6, VEGF, PDGF-bb), were found in normal-weight PCOS women compared to controls. Between normal-weight and obese PCOS women, there were no differences in hormonal, but in metabolic parameters. Obese PCOS women had significantly higher insulin resistance, fattyliver index, triglycerides, cytokines (IL-2, IL-13, IFN-γ). In healthy, but not in PCOS, women, there was a positive correlation of BPA with testosterone, SHBG with lutropine, and folitropine, while testosterone negatively correlated with SHBG. In obese women with PCOS, insulin resistance negatively correlated with SHBG and estradiol. No differences were observed in the paraben exposure. Levels of BPA were higher in PCOS women, indicating its role in the etiology. Obesity significantly worsens the symptoms., Markéta Šimková, Jana Vítků, Lucie Kolátorová, Jana Vrbíková, Michala Vosátková, Josef Včelák, Michaela Dušková., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

S279-S293

Source:

Physiological research | 2020 Volume:69 | Number:Supplement 2

Harvested from:

CDK

Metadata only:

false