Inverse association of lipoprotein (a) with markers of insulin resistance in dyslipidemic subjects

Title:

Inverse association of lipoprotein (a) with markers of insulin resistance in dyslipidemic subjects

Creator:

Helena Vaverková, David Karásek, Milan Halenka, Cibíčková, L., and Kubíčková, V.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:5021a73e-a07d-45ea-9590-068fb9e61351
uuid:5021a73e-a07d-45ea-9590-068fb9e61351
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, dyslipidémie, inzulinová rezistence, lipoproteiny, diabetes mellitus, dyslipidemia, insulin resistance, lipoproteins, lipoprotein (a), metabolic syndrome, type 2 diabetes mellitus, 14, and 612

Type:

article, články, journal articles, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Lipoprotein (a) [Lp(a)] is an LDL-like particle that contains an apolipoprotein B100 molecule covalently bound to a plasminogen-like glycoprotein, apolipoprotein (a) [apo(a)]. Epidemiological evidence supports a direct and causal association between Lp(a) levels and coronary risk. On the contrary, a few prospective findings demonstrate inverse association of Lp(a) levels with risk of type 2 diabetes (T2DM). The aim of our study was to evaluate the association of Lp(a) with indicators of insulin resistance (IR) and metabolic syndrome (MS), which precede development of T2DM. We enrolled 607 asymptomatic dyslipidemic subjects (295 men and 312 women, mea n age 45.6±14.0 years) into our cross-sectional study. Lp(a) concentrations correlated inversely with TG, AIP, insulin, HOMA, C-peptide, BMI, waist circumference, and number of MS components (p<0.01 for all). Subjects with MS had significantly lower Lp(a) concentrations in comparison with those without the presence of this phenotype (p<0.0001). Serum concentrations of Lp(a) in the lower (1th 3rd) quartiles of insulin and HOMA were significantly higher than in the 4 th quartile of these insulin resistance markers (p<0.001). Odds ratios of having increased markers of IR (TG, HOMA) and MS in top quartile of Lp(a) also indicate inverse association of Lp(a) with IR. The results of our study support an inverse association of Lp(a) levels with IR and MS that precedes overt T2DM diagnosis., H. Vaverková, D. Karásek, M. Halenka, L. Cibíčková, V. Kubíčková., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2017 Volume:66 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false