Organ Microcirculatory Disturbances in Experimental Acute Pancreatitis. A Role of Nitric Oxide

Title:

Organ Microcirculatory Disturbances in Experimental Acute Pancreatitis. A Role of Nitric Oxide

Creator:

Dobosz, M., Hac, S., Mionskowska, L., Dymecki, D., Dobrowolski, S., and Wajda, Z.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:4caa12a8-2825-46e4-85d0-6b400bc68165
uuid:4caa12a8-2825-46e4-85d0-6b400bc68165

Subject:

Acute pancreatitis, Microcirculation, and Nitric oxide

Type:

article, model:article, and TEXT

Description:

Microcirculatory disturbances are important early pathophysiological events in various organs during acute pancreatitis (AP). The aim of the study was to investigate an influence of L-arginine (nitric oxide substrate) and NG-nitro-L-arginine (L-NNA, nitric oxide synthase inhibitor) on organ microcirculation in experimental acute pancreatitis induced by four consecutive intraperitoneal cerulein injections (15 μg/kg/h). The microcirculation of pancreas, liver, kidney, stomach, colon and skeletal muscle was measured by laser Doppler flowmeter. Serum interleukin 6 and hematocrit levels were analyzed. AP resulted in a significant drop of microperfusion in all examined organ. L-arginine administration (2x100 mg/kg) improved the microcirculation in the pancreas, liver, kidney, colon and skeletal muscle, and lowered hematocrit levels. L-NNA treatment (2x25 mg/kg) caused aggravation of edematous AP to the necrotizing situation, and increased IL-6 and hematocrit levels. A further reduction of blood perfusion was noted in the stomach only. It is concluded that L-arginine administration has a positive influence on organ microcirculatory disturbances accompanying experimental cerulein-induced AP. NO inhibition aggravates the course of pancreatitis.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2005 Volume:54 | Number:4

Harvested from:

CDK

Metadata only:

false