Passive smoking impairs endothelium-dependent relaxation of isolated rabbit arteries

Title:

Passive smoking impairs endothelium-dependent relaxation of isolated rabbit arteries

Creator:

Török, J., Anna Gvozdjáková, Jarmila Kucharská, Ivan Balažovjech, Kyselá, S., Fedor Šimko, and Ján Gvozdják

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:4a415cbb-3608-4543-a9d3-56030b00c42f
uuid:4a415cbb-3608-4543-a9d3-56030b00c42f
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, pasivní kouření, hrudní aorta, passive smoking, thoracic aorta, cardiac hypertrophy, endothelium-dependent relaxation, carotid artery, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The aim of the present study was to examine the effect of prolonged passive smoking (lasting 3 weeks) on plasma catecholamine levels and reactivity of isolated rabbit arteries. Plasma noradrenaline, adrenaline and dopamine levels were determined radioenzymatically. Isolated rings of the thoracic aorta and carotid artery were suspended in organ chambers and connected to a force transducer for the recording of isometric tension. Plasma noradrenaline levels were found to be significantly elevated in rabbits subjected to passive smoking for 3 weeks. Plasma adrenaline and dopamine levels were not changed. Transmural nerve stimulation of arterial rings evoked frequency-dependent contractions. Prolonged passive smoking did not affect neurogenic contractions of the arteries tested. On the other hand, endothelium-dependent relaxations of phenylephrine-precontracted arteries were significantly impaired. Furthermore, hypertrophy of the left ventricle was observed. In conclusion, passive smoking impairs endothelium-dependent relaxations but not neurogenic contractions of systemic arteries. The impaired relaxations of arteries may be, at least in part, mediated through the degradation of released nitric oxide by superoxide anions derived from cigarette smoke., J. Török, A. Gvozdjáková, J. Kucharská, I. Balažovjech, S. Kyselá, F. Šimko, J. Gvozdják., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2000 Volume:49 | Number:1

Harvested from:

CDK

Metadata only:

false