Prenatal and perinatal factors influencing nociception, addiction and behavior during ontogenetic development

Title:

Prenatal and perinatal factors influencing nociception, addiction and behavior during ontogenetic development

Creator:

Richard Rokyta, Anna Yamamotová, Romana Šlamberová, Miloslav Franěk, Šimon Vaculín, Hrubá, L., Barbora Schutová, and Marie Pometlová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:4678984a-1e89-450d-bb05-dcf361125510
uuid:4678984a-1e89-450d-bb05-dcf361125510
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, neurofyziologie, pervitin, ontogeneze, neurophysiology, methamphetamine, ontogeny, nociception, hippocampus, rhizotomy, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

This review, which summarizes our findings concerning the long-term effects of pre-, peri- and postnatal factors affecting development, nociception and sensorimotor functions, focuses on three areas: 1) perinatal factors influencing nociception in adult rats were examined in rats with hippocampal lesions, after the administration of stress influencing and psychostimulant drugs (dexamethasone, indomethacine and methamphetamine); 2) the effect of pre- and early postnatal methamphetamine administration was shown to impair the development of sensorimotor functions tested in rat pups throughout the preweaning period; 3) the effect of extensive dorsal rhizotomy of the brachial plexus during the early postnatal period was studied with respect to neuropathic pain development and sensorimotor functions. The present study indicates that prenatal or neonatal stress, as well as various drugs, may disturb the development of the nociceptive system and cause long-term behavioral changes persisting to adulthood and that some types of neuropathic pain cannot be induced during the first two postnatal weeks at all. A mature nervous system is required for the development of the described pathological behaviors., R. Rokyta, A. Yamamotová, R. Šlamberová, M. Franěk, Š. Vaculín, L. Hrubá, B. Schutová, M. Pometlová., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:Suppl 3

Harvested from:

CDK

Metadata only:

false