Pulmonary surfactant and bacterial lipopolysaccharide: the interaction and its functional consequences

Title:

Pulmonary surfactant and bacterial lipopolysaccharide: the interaction and its functional consequences

Creator:

Kolomaznik, M., Nova, Z., and Andrea Čalkovská

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:45759ae6-638f-49f4-a98f-c1bd91cbc2cd
uuid:45759ae6-638f-49f4-a98f-c1bd91cbc2cd
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, plíce, lungs, lipopolysaccharide, pulmonary surfactant, inhibition, alveolar type II cells, lung injury, 14, and 612

Type:

article, články, journal articles, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The respiratory system is constantly exposed to pathogens which enter the lungs by inhalation or via blood stream. Lipopolysaccharide (LPS), also named endotoxin, can reach the airspaces as the major component of the outer membrane of Gram-negative bacteria, and lead to local inflammation and systemic toxicity. LPS affects alveolar type II (ATII) cells an d pulmonary surfactant and although surfactant molecule has the effective protective mechanisms, excessive amount of LPS interacts with surfactant film and leads to its inactivation. From immunological point of view, surfactant specific proteins (SPs) SP-A and SP-D are best characterized, however, there is increasing evidence on the involvement of SP-B and SP-C and certain phospholipids in immune reactions. In animal models, the instillation of LPS to the respiratory system induces acute lung injury (ALI). It is of clinical importance that endotoxin-induced lung injury can be favorably influenced by intratracheal instillation of exogenous surfactant. The beneficial effect of this treatment was confirmed for both natural porcine and synthetic surfactants. It is believed that the surfactant preparations have anti-inflammatory properties through regulating cytokine production by inflammatory cells. The mechanism by which LPS interferes with ATII cells and surfactant layer, and its consequences are discussed below., M. Kolomaznik, Z. Nova, A. Calkovska., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2017 Volume:66 | Number:Suppl 2

Harvested from:

CDK

Metadata only:

false