Effects of isoflurane concentration on basic echocardiographic parameters of the left ventricle in rats

Title:

Effects of isoflurane concentration on basic echocardiographic parameters of the left ventricle in rats

Creator:

Říha, H., František Papoušek, Jan Neckář, Jan Pirk, and Bohuslav Ošťádal

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:454e3733-c56d-478b-97a5-d164e9a0b6cc
uuid:454e3733-c56d-478b-97a5-d164e9a0b6cc

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, anesthesia, isoflurane, echocardiography, left ventricular function, rat heart, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Transthoracic echocardiography (TTE) has become an important modality for the assessment of cardiac structure and function in animal experiments. The acquisition of echocardiographic images in rats requires sedation/anesthesia to keep the rats immobile. Commonly used anesthetic regimens include intraperitoneal or inhalational application of various anesthetics. Several studies have compared the effects of anesthetic agents on echocardiographic parameters in rats; however, none of them examined the effects of different concentrations of inhalational anesthetics on echocardiographic parameters. Accordingly, the aim of this study was to examine the effects of different concentrations of isoflurane used for anesthesia during TTE examination in rats on basic echocardiographic parameters of left ventricular (LV) anatomy and systolic function. TTE examinations were performed in adult male Wistar rats (n=10) anesthetized with isoflurane at concentrations of 1.5-3 %. Standard echocardiograms were recorded for off-line analysis. An absence of changes in basic echocardiographic parameters of LV anatomy and systolic function was found under isoflurane anesthesia using concentrations between 1.5-2.5 %. An isoflurane concentration of 3 % caused a small, but statistically significant, increase in LV chamber dimensions without a concomitant change in heart rate or fractional shortening. For the purpose of TTE examination in the rat, our results suggest that isoflurane concentrations ≤ 2.5 % can be safely recommended., H. Říha ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2012 Volume:61 | Number:4

Harvested from:

CDK

Metadata only:

false