Are there sex differences in the reaction of undercarboxylated osteocalcin to hypoglycemia?

Title:

Are there sex differences in the reaction of undercarboxylated osteocalcin to hypoglycemia?

Creator:

Dušková, Michaela, Kolátorová Sosvorová, Lucie, Jandíková, Hana, Pospíšilová, Hana, and Stárka, Luboslav

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:437d1f65-918d-46b1-84f9-fec3bc5d8f57
uuid:437d1f65-918d-46b1-84f9-fec3bc5d8f57
issn:0862-8408
doi:10.33549/physiolres.934520

Subject:

hypoglykémie, pohlavní rozdíly, hypoglycemia, sex differences, undercarboxylated osteocalcin, Insulin tolerance test, 14, and 612

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

There has been increasing evidence in recent years for the hypothesis of bones as endocrine organs. Osteocalcin, long considered just a marker of new bone formation, is now seen as the first hormone produced by bones, and seems to be associated with regulating glucose metabolism and reproduction. The aim of this work was to monitor changes of osteocalcin in reaction to hypoglycemia, and determine if there are differences in such reactions between the sexes. The study included 61 healthy probands with physiological calciophosphate metabolism (30 men and 31 women). We applied to each of them an insulin tolerance test, and then monitored levels of undercarboxylated osteocalcin and reactions to hypoglycemia at regular time intervals. We found differences in the reaction to hypoglycemia between the sexes. In men there was a significant decline in undercarboxylated osteocalcin between the 30 and 40 min (p<0.0015), which reflects a reaction to a glycemic decline between 25-30 min, followed by reversal. Low undercarboxylated osteocalcin in men lasted up to 90 min, after which they returned to levels before the test. In women we did not find any significant changes in undercarboxylated osteocalcin levels. Changes in undercarboxylated osteocalcin induced by hypoglycemia indicate a relationship between bones and glucose metabolism. There was an interesting difference between the sexes. However, a definitive conclusion about the role of osteocalcin in human metabolism will require numerous future studies., Michaela Dušková, Lucie Kolátorová, Hana Jandíková, Hana Pospíšilová, Luboslav Stárka., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

S315-S320

Source:

Physiological research | 2020 Volume:69 | Number:Supplement 2

Harvested from:

CDK

Metadata only:

false