Study on the pharmicological character of an insulin-mimetic small molecular compound of vanadyl trehalose

Title:

Study on the pharmicological character of an insulin-mimetic small molecular compound of vanadyl trehalose

Creator:

Umar, Muhammad, Qian, Wei, Liu, Qiqi, Xing, Shuguang, Li, Xiaodan, Yang, Xingkai, Fan, Yu, Ma, Daocheng, Jiang, Pingzhe, and Li, Minggang

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:3d69713e-522c-4a9b-a9ef-8f08fe6b6bc5
uuid:3d69713e-522c-4a9b-a9ef-8f08fe6b6bc5
doi:10.33549/physiolres.934370

Subject:

vanadyl trehalose, oxidative stress, GSH/GSTs, vitamin C, and glutathione

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

To investigate the effect of vanadyl trehalose (VT) on oxidative stress and reduced glutathione/glutathione-Stransferase（GSH/GSTs）pathway gene expression in mouse gastrointestinal tract, as well as the protective effects of vitamin C (VC) and reduced glutathione (GSH). Thirty male Kunming mice were randomly divided into five groups: control group (group A), VT group (group B), VC + VT group (group C), GSH + VT group (group D) and VC + GSH + VT group (group E). The content of reduced glutathione (GSH) and glutathione peroxidase (GSH-Px) activity and the expressions of glutamatecysteine ligase catalytic subunit (GCLC), glutathione synthetase (GSS), regulated through glutathione reductase (GSR) and glutathione-S-transferase pi (GSTpi) in stomach and duodenum in vanadyl trehalose treated group were lower than those in group A (P<0.05). The C, D, E group can significantly improve the above indicators, but those only in the stomach in E group reached the level of the control group. Vanadyl trehalose (VT) was able to cause oxidative stress damage to the gastrointestinal tract of mice, which affects GSH content and GSH-Px activity and interferes with the normal expression of GSH/GSTs pathway. Exogenous vitamin C, reduced glutathione and the combination of the two could play a specific role in antioxidant protection and reduce the toxicity of vanadyl trehalose.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

481-490

Source:

Physiological research | 2020 Volume:69 | Number:3

Harvested from:

CDK

Metadata only:

false