Biochemical and biophysical aspects of collagen nanostructure in the extracellular matrix

Title:

Biochemical and biophysical aspects of collagen nanostructure in the extracellular matrix

Creator:

Koláčná, L., Bakešová, J., Ferdinand Varga, Eva Košťáková, Ladislav Plánka, Alois Nečas, David Lukáš, Evžen Amler, and Václav Pelouch

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:3c7acba5-88a9-48d6-8472-d75fdc31ab96
uuid:3c7acba5-88a9-48d6-8472-d75fdc31ab96
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, kolagen, nanovlákna, popraviště, collagen, nanofibers, scaffolds, extracellular matrix, biomechanical properties, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

ECM is composed of different collagenous and non-collagenous proteins. Collagen nanofibers play a dominant role in maintaining the biological and structural integrity of various tissues and organs, including bone, skin, tendon, blood vessels, and cartilage. Artificial collagen nanofibers are increasingly significant in numerous tissue engineering applications and seem to be ideal scaffolds for cell growth and proliferation. The modern tissue engineering task is to develop three-dimensional scaffolds of appropriate biological and biomechanical properties, at the same time mimicking the natural extracellular matrix and promoting tissue regeneration. Furthermore, it should be biodegradable, bioresorbable and non-inflammatory, should provide sufficient nutrient supply and have appropriate viscoelasticity and strength. Attributed to collagen features mentioned above, collagen fibers represent an obvious appropriate material for tissue engineering scaffolds. The aim of this minireview is, besides encapsulation of the basic biochemical and biophysical properties of collagen, to summarize the most promising modern methods and technologies for production of collagen nanofibers and scaffolds for artificial tissue development., L. Koláčná, J. Bakešová, F. Varga, E. Košťáková, L. Plánka, A. Nečas, D. Lukáš, E. Amler, V. Pelouch., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2007 Volume:56 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false