Indoleamine 2,3-dioxygenase (IDO) regulates Th17/ Treg immunity in experimental IgA nephropathy

Title:

Indoleamine 2,3-dioxygenase (IDO) regulates Th17/ Treg immunity in experimental IgA nephropathy

Creator:

Yang, Y., Liu, K., Chen, Y., Gong, Y., and Liang, Y.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:37a5b617-5aa2-4950-a0a2-d552542e6f83
uuid:37a5b617-5aa2-4950-a0a2-d552542e6f83

Subject:

IgA nephropathy, IDO, Th17, Treg, and cytokine

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide. Current studies have shown that the Th17/Treg immune balance may be involved in the occurrence of IgAN, but the exact mechanism is still unclear. Indoleamine 2,3-dioxygenase (IDO) is an enzyme that catalyses degradation of tryptophan (Trp) through the kynurenine (Kyn) pathway; it can control inflammation and immune response by inducing Trp starvation. IDO may be a key molecule in regulating the Th17/Treg immune balance. However, it is not clear whether IDO is involved in the IgAN disease occurrence by regulating the Th17/Treg immune balance. In this study, an IgAN mouse model was established. The mice were intraperitoneally inoculated with IDO inhibitor 1-MT or agonist ISS-ODN to observe whether the IDO signalling pathway participates in the occurrence and development of IgAN by regulating the Th17/Treg immune balance. The results showed that IDO inhibitor 1-MT significantly increased renal injury and glomerular IgA accumulation and up-regulated Th17/Treg and Th17-related cytokine expression in IgAN mice, while ISS-ODN significantly decreased renal injury and glomerular IgA accumulation, down-regulated Th17/Treg expression and inhibited Th17-related cytokine expression in IgAN mice. In conclusion, IDO was involved in the occurrence and progress of IgAN by regulating the Th17/Treg balance. and Corresponding author: Yumei Liang

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

[101]-108

Source:

Folia biologica | 2019 Volume:65 | Number:2

Harvested from:

CDK

Metadata only:

false