Postnatal development of energy metabolism in the rat brain

Title:

Postnatal development of energy metabolism in the rat brain

Creator:

Martin Kalous, Hana Rauchová, and Zdeněk Drahota

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:33617d46-4f21-4d1f-aa13-39ddc009b459
uuid:33617d46-4f21-4d1f-aa13-39ddc009b459
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, energetický metabolismus, cytochromy, energy metabolism, cytochromes, brain mitochondria, cytochrome c oxidase, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The activities of cytochrome c oxidase and FoF1-ATPase as well as the content of cytochromes cc1, aa3, and b were investigated in free brain mitochondria in the course of postnatal development and aging. The results show an increase of Vmax of both enzymes during postnatal development (between day 5 and 30). During the following phase ending at the age of 6 months, a decrease of FoF1-ATPase and cytochrome c oxidase activity occurs. From 6 to 12 months of age the activity of these enzymes did not change. The KM for both enzymes remained unchanged during the whole period observed. The content of cytochromes increased from the low values found in young rats, reached the highest values at around one month, and decreased till the age of 3 months. Later, their content in brain mitochondria did not markedly change. Our results suggest that the metabolic maturation of brain mitochondria differs in several aspects from the same process in other tissues, mainly in the time course. This is probably due to the unique role of neural tissue in the organism., M. Kalous, H. Rauchová, Z. Drahota., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2001 Volume:50 | Number:3

Harvested from:

CDK

Metadata only:

false