A polymorphism in the cyclooxygenase 2 gene in type 1 diabetic patients with nephropathy

Title:

A polymorphism in the cyclooxygenase 2 gene in type 1 diabetic patients with nephropathy

Creator:

Hubáček, J. A., Terezie Pelikánová, Věra Lánská, and Radko Komers

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:32f0dae8-3489-4e40-9368-4c70886be5a7
uuid:32f0dae8-3489-4e40-9368-4c70886be5a7

Subject:

Fyziologie člověka a srovnávací fyziologie, cyklooxygenáza 2, diabetická nefropatie, polymorfismus, cyclooxygenase 2, diabetic nephropathy, polymorphism, -765G>C polymorphism, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Diabetic nephropathy (DN), the most serious complication of Type 1 diabetes (DM1), has a strong genetic component. Cyclooxygenase-2 (COX-2), an in ducible enzyme by a number of stimuli, has been implicated in pathophysiology of cardiovascular and renal disease, including DN. The allele -765C, of the -765G>C polymorphism (rs20417) in the COX-2 promoter has lower promoter activity compared with the -765G allele and protective effects in cardiovascular disease. This polymorphism was not investigated in patients with DM1 and nephropathy. The study was conducted in 779 Caucasian patients with DM1 and compared to a representative sample of healthy Czech population. The patients demonstr ated lower frequencies of the CC genotype (P=0.005). From th e DM1 cohort, 153 patients met the criteria for low risk of the development of DN (LRDN, duration of DM1>10 years, normoalbuminuria, normotension) and 139 patients had manifest DN. There were no differences in -765G>C polymorphisms between LRDN and DN patients. Moreover, the C/G allele frequenc ies did not also differ between the groups. In conclusion, patients with DM1 display lower freqencies of the protective CC genotype as compared to healthy subjects. However, the study did not reveal associations of -765G>C polymorphism with the risk of DN., J. A. Hubáček ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:2

Harvested from:

CDK

Metadata only:

false