Does neonatal brain ischemia induce schizophrenia-like behaviour in young adult rats?

Title:

Does neonatal brain ischemia induce schizophrenia-like behaviour in young adult rats?

Creator:

Hana Tejkalová, Kaiser, M., Jan Klaschka, and František Šťastný

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:311209a1-f904-45d6-8ef8-b7dee194c3f6
uuid:311209a1-f904-45d6-8ef8-b7dee194c3f6
issn:0862-8408

Subject:

Biochemie. Molekulární biologie. Biofyzika, biochemie, neurochirurgie, schizofrenie, potkan, biochemistry, neurosurgery, schizophrenia, Rattus norvegicus, neonatal ischemia, prepulse inhibition, 2, and 577

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Perinatal cerebral hypoxia represents a major cause of obstetric complications and the resulting transient oxygen deficiency might belong to early risk factors for schizophrenia. The aim of this study was to evaluate possible long-term behavioral changes induced by one hour of continuous bilateral common carotid artery occlusion in 12-day-old male rats. Post-ischemic behavioral disturbances were evaluated in social (play) behavior on postnatal day 22 (PND 22), open field test (PND 35 and 50) and prepulse inhibition of the acoustic startle reflex (PND 50). Transient ischemia in neonatal rats was not significantly altered in social dyadic interactions evaluated in pre-weaning pups, but resulted in enhanced locomotor activity in pubertal rats (PND 35) and impaired prepulse inhibition of the startle reflex in post- pubertal males (PND 50). These behavioral alterations suggest that perinatal hypoxic/ischemic insults may represent a risk factor for later manifestation of specific features relevant to schizophrenia in predisposed individuals., F. Tejkalová, M. Kaiser, J. Klaschka, F. Šťastný., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2007 Volume:56 | Number:6

Harvested from:

CDK

Metadata only:

false