Side effects of amino acid supplements

Title:

Side effects of amino acid supplements

Creator:

Holeček, Milan

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:297a59f3-e5ee-410d-884e-488bff29ee26
uuid:297a59f3-e5ee-410d-884e-488bff29ee26
doi:10.33549/physiolres.934790

Subject:

arginine, branched-chain amino acids, carnosine, citrulline, creatine, glutamine, histidine, and tryptophan

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

The aim of the article is to examine side effects of increased dietary intake of amino acids, which are commonly used as a dietary supplement. In addition to toxicity, mutagenicity and carcinogenicity, attention is focused on renal and gastrointestinal tract functions, ammonia production, and consequences of a competition with other amino acids for a carrier at the cell membranes and enzymes responsible for their degradation. In alphabetic order are examined arginine, β-alanine, branchedchain amino acids, carnosine, citrulline, creatine, glutamine, histidine, β-hydroxy-β-methylbutyrate, leucine, and tryptophan. In the article is shown that enhanced intake of most amino acid supplements may not be risk-free and can cause a number of detrimental side effects. Further research is necessary to elucidate effects of high doses and long-term consumption of amino acid supplements on immune system, brain function, muscle protein balance, synthesis of toxic metabolites, and tumor growth and examine their suitability under certain circumstances. These include elderly, childhood, pregnancy, nursing a baby, and medical condition, such as diabetes and liver disease. Studies are also needed to examine adaptive response to a long-term intake of any substance and consequences of discontinuation of supplementation.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

29-45

Source:

Physiological research | 2022 Volume:71 | Number:1

Harvested from:

CDK

Metadata only:

false