High-mobility group box-1 protein in adenine-induced chronic renal failure and the influence of gum arabic thereon

Title:

High-mobility group box-1 protein in adenine-induced chronic renal failure and the influence of gum arabic thereon

Creator:

Ali, B. H., Al Za'abi, M., Al Shukaili, A., and Nemmar, A.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:28e271f9-2e0c-4ac4-955a-d4c32257d7b4
uuid:28e271f9-2e0c-4ac4-955a-d4c32257d7b4
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, chronic renal failure, rats, adenine, gum arabic, high-mobility group box-1 protein, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Pathogenesis of adenine-induced chronic renal failure may involve inflammatory, immunological and/or oxidant mechanisms. Gum arabic (GA) is a complex po lysaccharide that acts as an anti-oxidant which can modulate inflammatory and/or immunological processes. Therefore, we tested here the effect of GA treatment (15 % in the drinking water for 4 weeks) in plasma and urine of rats, on a novel cytokine that has been shown to be pro-inflammatory, viz, DNA-binding high-mobility group box-1 protein (HMGB1). Adenine (0.75 % in the feed, 4 weeks) significantly increased indoxyl sulphate, urea and creatinine concentrations in plasma, an d significantly decreased the creatinine clearance. GA significantly abated these effects. The concentrations of HMGB1 in urine before the start of the experiment were similar in all four groups. However, 24 h after the last treatment, adenine treatment increased significantly the concentration of HMGB1 when compared with the control. GA treatment did not affect the HMGB1 concentration in urine. Moreover, the concentration of HMGB1 in plasma obtained 24 h after the last treatment in rats treated with adenine was drastically reduced compared with the control group. This may explain its significant rise in urine. In conclusion, HMGB1 can be considered a potentially useful biomarker in adenine induced CRF and its treatment., B. H. Ali, M. Al Za'abi, A. Al Shukaili, A. Nemmar., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:1

Harvested from:

CDK

Metadata only:

false