The role of membrane fluidity changes and thiobarbituric acid-reactive substrances production in the inhibition of cerebral cortex Na+/K+-ATPase activity

Title:

The role of membrane fluidity changes and thiobarbituric acid-reactive substrances production in the inhibition of cerebral cortex Na+/K+-ATPase activity

Creator:

Hana Rauchová, Zdeněk Drahota, and Jitka Koudelová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:204f48fc-1e25-4d12-b6aa-bd8bba1504c2
uuid:204f48fc-1e25-4d12-b6aa-bd8bba1504c2
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, cerebral cortex membranes, lipid peroxidation, membrane fluidity, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Lipid peroxidation of rat cerebral cortex membranes was induced by Fe2+/ADP and ascorbate. The rate of Na+/K+-ATPase inhibition was correlated with the increase of thiobarbituric acid-reactive substances (TBARS) and conjugated dienes (CD) and with membrane fluidity changes. Our data showed that membrane fluidity changes (evaluated by fluorescence steady-state anisotropy measurements) can participate in Na+/K+-ATPase inhibition during the initial period of lipid peroxidation process, whereas during the following period the enzyme inhibition correlates only with TBARS and CD production., H. Rauchová, Z. Drahota, J. Koudelová., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1999 Volume:48 | Number:1

Harvested from:

CDK

Metadata only:

false