Effects of beta-hydroxy-beta-methylbutyrate in partially hepatectomized rats

Title:

Effects of beta-hydroxy-beta-methylbutyrate in partially hepatectomized rats

Creator:

Milan Holeček and Vodeničarovová, M

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:1eda66a4-b4bb-4c62-948a-9f3d96f1d99e
uuid:1eda66a4-b4bb-4c62-948a-9f3d96f1d99e
issn:0862-8408

Subject:

fyziologie, physiology, branched-chain amino acids, supplements, liver regeneration, muscle wasting, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

Beta-hydroxy-beta-methylbutyrate (HMB) is a leucine metabolite with protein anabolic effects. Since HMB is synthesized in the liver, unique effects of exogenous HMB intake may be hypothesized in subjects with liver disease, in which muscle wasting is frequently found. We studied effects of HMB on the liver and soleus (SOL) and extensor digitorum longus (EDL) muscles in partially-hepatectomized (PH) rats. HMB or saline was infused using osmotic pumps to PH or sham-operated rats for 7 days. We found lower body weight and protein content in EDL of PH rats treated with saline than in sham-operated animals. These effects were insignificant in HMB treated animals. In blood plasma of PH rats treated with HMB we found lower concentrations of creatinine and higher concentrations of urea and branched-chain amino acids (BCAA; valine, leucine, and isoleucine) than in PH animals treated with saline. HMB increased BCAA concentrations in SOL and EDL of PH animals and decreased proteolysis in EDL of both sham-operated and PH animals. In the livers of PH rats treated with HMB we found higher DNA content, DNA fragmentation, and BCAA concentrations than in saline-treated animals. The results indicate that HMB affects metabolism of BCAA and has positive influence on protein balance in muscles. Further studies are needed to clarify the effect of HMB on liver regeneration., M. Holeček, M. Vodeničarovová., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:5

Harvested from:

CDK

Metadata only:

false