Sex differences in the effect of prenatal testosterone exposure on steroid hormone production in adult rats
- Title:
- Sex differences in the effect of prenatal testosterone exposure on steroid hormone production in adult rats
- Creator:
- Domonkos, E., Borbélyová, V., Lucie Kolátorová Sosvorová, Chlupáčová, T., Daniela Ostatníková, Július Hodosy, Luboslav Stárka, and Peter Celec
- Identifier:
- https://cdk.lib.cas.cz/client/handle/uuid:1e0c840c-e904-44df-a8a0-27ce024e7572
uuid:1e0c840c-e904-44df-a8a0-27ce024e7572
issn:0862-8408 - Subject:
- Fyziologie člověka a srovnávací fyziologie, estrogeny, glukokortikoidy, estrogens, glucocorticoids, prenatal androgenization, androgen, gonadotropins, steroidogenesis, 14, and 612
- Type:
- article, články, journal articles, model:article, and TEXT
- Format:
- print, bez média, and svazek
- Description:
- Maternal hyperandrogenism during pregnancy might have metabolic and endocrine consequences on the offspring as shown for the polycystic ovary syndrome. Despite numerous experiments, the impact of prenatal hyperandrogenic environment on postnatal sex steroid milieu is not yet clear. In this study, we investigated the effect of prenatal testosterone excess on postnatal concentrations of luteinizing hormone, corticosterone and steroid hormones including testosterone, pregnenolone, progesterone, estradiol and 7β-hydroxyepiandrosterone in the offspring of both sexes. Pregnant rats were injected daily with either testosterone propionate or vehicle from gestational day 14 until parturition. The hormones were evaluated in plasma of the adult offspring. As expected, females had lower testosterone and higher pregnenolone, progesterone and estradiol in comparison to males. In addition, corticosterone was higher in females than in males, and it was further elevated by prenatal testosterone treatment. In males, prenatal testosterone exposure resulted in higher 7β-hydroxyepiandrosterone in comparison to control group. None of the other analyzed hormones were affected by prenatal testosterone. In conclusion, our results did not show major effects on sex hormone production or luteinizing hormone release in adult rats resulting from testosterone excess during their fetal development. However, maternal hyperandrogenism seems to partially affect steroid biosynthesis in sex-specific manner., E. Domonkos, V. Borbélyová, L. Kolátorová, T. Chlupáčová, D. Ostatníková, J. Hodosy, L. Stárka, P. Celec., and Obsahuje bibliografii
- Language:
- English
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/
policy:public - Source:
- Physiological research | 2017 Volume:66 | Number:Suppl 3
- Harvested from:
- CDK
- Metadata only:
- false
The item or associated files might be "in copyright"; review the provided rights metadata:
- http://creativecommons.org/publicdomain/mark/1.0/
- policy:public