Interaction of perivascular adipose tissue and sympathetic nerves in arteries from normotensive and hypertensive rats

Title:

Interaction of perivascular adipose tissue and sympathetic nerves in arteries from normotensive and hypertensive rats

Creator:

Török, J., Zemančíková, A., and Kocianová, Z.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:1c930da4-9775-45a3-a7e9-406842de1ead
uuid:1c930da4-9775-45a3-a7e9-406842de1ead

Subject:

Perivascular adipose tissue, Mesenteric artery, Abdominal aorta, Adrenergic contraction, and Spontaneously hypertensive rats

Type:

article, model:article, and TEXT

Description:

The inhibitory action of perivascular adipose tissue (PVAT) in modulation of arterial contraction has been recently recognized and contrasted with the prohypertensive effect of obesity in humans. In this study we demonstrated that PVAT might have opposing effect on sympatho-adrenergic contractions in different rat conduit arteries. In superior mesenteric artery isolated from normotensive Wistar-Kyoto rats (WKY), PVAT exhibited inhibitory influence on the contractions to exogenous noradrenaline as well as to endogenous noradrenaline released from art erial sympathetic nerves during transmural electrical stimulation or after application of tyramine. In contrast, the abdominal aortawith intact PVAT responded with larger contractions to transmural electrical stimulation and tyramine when compared to the aorta after removing PVAT; the responses to noradrenalinewere similar in both. This indicates that PVAT may contain additional sources of endogenous noradrenaline which could be responsible for the main difference in the modulatory effect of PVAT on adrenergic contractions between abdominal aortas and superior mesenteric arteries. In spontaneously hypertensive rats (SHR), the anticontractile effect of PVAT in mesenteric arteries was reduced, and the removal of PVAT completely eliminated the difference in the dose-response curves to exogenous noradrenaline between SHR and WKY. These results suggest that in mesenteric artery isolated from SHR, the impairedanticontractile influence of PVAT might significantly contribute to its increased sensitivity to adrener gic stimuli.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2016 Volume:65 | Number:Suppl 3

Harvested from:

CDK

Metadata only:

false