Daily subacute paraquat exposure decreases muscle function and substantia nigra dopamine level

Title:

Daily subacute paraquat exposure decreases muscle function and substantia nigra dopamine level

Creator:

Fahim, M. A., Shehab, S., Nemmar, A., Adem, A., Dhanasekaran, S., and Hasan, M. Y.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:194e5808-787a-4b6f-a43b-eafa5248793d
uuid:194e5808-787a-4b6f-a43b-eafa5248793d

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, paraquat, dopamine, skeletal muscle, locomotor activity, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

The use of the herbicide paraquat (1,1'-dimethyl-4,4'-bipyridylium dichloride; PQ) which is widely used in agriculture is known to cause dopaminergic neurotoxicity. However, the mechanisms underlying this effect are not fully understood. This present study investigated the behavioral manifestations, motor coordination, and dopaminergic neurodegeneration following exposure to PQ. Male rats were injected with PQ (10 mg/kg i.p.) daily for three weeks. Rotarod systems were used for measuring locomotor activity and motor coordination. The effects of PQ on dorsiflexor, electrophysiologically-induced muscle contraction were studied. Dopamine concentrations in the ventral mesencephalon were measured by high performance liquid chromatography and the number of dopaminergic neurons in substantia nigra pars compacta was estimated by tyrosine hydroxylase immunohistochemistry. PQ induced difficulty in movement and significant reduction in motor activity and twitch tension at the dorsiflexor skeletal muscle. The number of tyrosine hydroxylase positive neurons was significantly less in the substantia nigra pars compacta and nigral dopamine level was significantly reduced in PQ treated animals (20.4±3.4 pg/mg) when compared with control animals (55.0±2.4 pg/mg wet tissue). Daily treatment of PQ for three weeks induces selective dopaminergic neuronal loss in the substantia nigra and significant behavioral and peripheral motor deficit effects., M. A. Fahim, ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2013 Volume:62 | Number:3

Harvested from:

CDK

Metadata only:

false