Adiponectin as a potential marker of prostate cancer progression: studies in organ-confined and locally advanced prostate cancer

Title:

Adiponectin as a potential marker of prostate cancer progression: studies in organ-confined and locally advanced prostate cancer

Creator:

Daniel Housa, Zdenka Vernerová, Jiří Heráček, Bohumír Procházka, Petr Čechák, Jitka Kuncová, and Martin Haluzík

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:1830d430-4f90-424c-80a0-3d7f09964a4e
uuid:1830d430-4f90-424c-80a0-3d7f09964a4e
issn:0862-8408

Subject:

Biochemie. Molekulární biologie. Biofyzika, lékařská biochemie, rakovina prostaty, imunohistochemie, medical biochemistry, prostate cancer, immunohistochemistry, adiponektin, adiponectin, 2, and 577

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Serum levels of adiponectin were measured in patients with benign prostatic hyperplasia and prostate cancer of pT2 and pT3 stage. Adiponectin ELISA assay, immunohistochemistry, and selected metabolic and biochemical parameters measurement was performed in 25 patients with benign prostatic hyperplasia and 43 with prostate cancer (17 patients with organ-confined and 26 patients with locally advanced disease). Serum adiponectin levels did not differ between prostate benign hyperplasia and cancer clinical stage T2, but was significantly higher in pT3 relative to pT2 group (14.51± 4.92 vs. 21.41±8. 12, P = 0.003). Tissue immunohistochemistry showed enhanced staining in neoplastic prostate glands and intraepithelial neoplasia relative to benign prostatic hyperplasia without distinction between disease grade and stage. Serum adiponectin levels are higher in locally advanced relative to organ-confined prostate cancer and may thus serve as an auxiliary marker providing further improvement for discrimination between pT2 and pT3 stages., D. Housa, Z. Vernerová, J. Heráček, B. Procházka, P. Čechák, J. Kuncová, M. Haluzík., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:3

Harvested from:

CDK

Metadata only:

false