Changes of calcium binding protein expression in spinothalamic tract neurons after peripheral inflammation

Title:

Changes of calcium binding protein expression in spinothalamic tract neurons after peripheral inflammation

Creator:

David Sojka, Gabriela Zacharová, D. Spicarova, and Jiří Paleček

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:14f6cde9-c4f0-4d96-b735-8216678a631d
uuid:14f6cde9-c4f0-4d96-b735-8216678a631d
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, artritida, arthritis, calbindin, parvalbumin, calretinin, synaptic plasticity, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Specific neuronal populations are known to express calcium binding proteins (CBP) such as calbindin (CB), parvalbumin (PV) and calretinin (CR). These CBP can act as calcium buffers that modify spatiotemporal characteristics of intracellular calcium transients and affect calcium homeostasis in neurons. It was recently shown that changes in neuronal CBP expression can have significant modulatory effect on synaptic transmission. Spinothalamic tract (STT) neurons form a major nociceptive pathway and they become sensitized after peripheral inflammation. In our experiments, expression of CBP in STT neurons was studied in a model of unilateral acute knee joint arthritis in rats. Altogether 377, 374 and 358 STT neurons in the segments L3-4 were evaluated for the presence of CB, PV and CR. On the contralateral (control) side 11 %, 9 % and 47 % of the retrogradely labeled STT ne urons expressed CB, PV and CR, respectively. On the ipsilateral (arthritic) side there was significantly more CB (23 %) and PV (25 %) expressing STT neurons, while the number of CR positive neurons (50 %) did not differ. Our results show increased expression of fast (CB) and slow (PV) calcium binding proteins in STT neurons after induction of experimental arthritis. This suggests that change in CBP expression could have a significant effect on calcium homeostasis and possibly modulation of synaptic activity in STT neurons., D. Sojka, G. Zacharova, D. Spicarova, J. Palecek., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2010 Volume:59 | Number:6

Harvested from:

CDK

Metadata only:

false