The influence of n-3 polyunsaturated fatty acids and very low calorie diet (VLCD) during a short-term weight reducing regimen on weight loss and serum fatty acid composition in severely obese women

Title:

The influence of n-3 polyunsaturated fatty acids and very low calorie diet (VLCD) during a short-term weight reducing regimen on weight loss and serum fatty acid composition in severely obese women

Creator:

Kunešová, M., Braunerová, R., Hlavatý, P., Tvrzická, E., Staňková, B., Škrha, J., Hilgertová, J., Hill, M., Kopecký, J., Wagenknecht, M., Hainer, V., Matoulek, M., Pařízková, J., Žák, A., and Svačina, Š.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:0463896e-3eec-486e-a47a-c05f6eeb75fd
uuid:0463896e-3eec-486e-a47a-c05f6eeb75fd

Subject:

Obesity treatment, Fatty acid composition, very low calorie diet, Beta-hydroxybutyrate, and PUFA

Type:

article, model:article, and TEXT

Description:

Polyunsaturated fatty acids of n-3 series (n-3 PUFA) were shown to increase basal fat oxidation in humans. The aim of the study was to compare the effect of n-3 PUFA added to a very low calorie diet (VLCD), with VLCD only during three-week inpatient weight reduction. Twenty severely obese women were randomly assigned to VLCD with n-3 PUFA or with placebo. Fatty acids in serum lipid fractions were quantified by gas chromatography. Differences between the groups were determined using ANOVA. Higher weight (7.55±1.77 vs. 6.07±2.16 kg, NS), BMI (2.82± 0.62 vs. 2.22±0.74, p<0.05) and hip circumference losses (4.8±1.81 vs. 2.5±2.51cm, p<0.05) were found in the n-3 group as compared to the control group. Significantly higher increase in beta-hydroxybutyrate was found in the n-3 group showing higher ketogenesis and possible higher fatty acid oxidation. The increase in beta-hydroxybutyrate significantly correlated with the increase in serum phospholipid arachidonic acid (20:4n-6; r = 0.91, p<0.001). In the n-3 group significantly higher increase was found in n-3 PUFA (eicosapentaenoic acid, 20:5n-3, docosahexaenoic acid, 22:6n-3) in trigycerides and phospholipids. The significant decrease of palmitoleic acid (16:1n-7) and vaccenic acid (18:1n-7) in triglycerides probably reflected lower lipogenesis. A significant negative correlation between BMI change and phospholipid docosahexaenoic acid change was found (r = -0.595, p<0.008). The results suggest that long chain n-3 PUFA enhance weight loss in obese females treated by VLCD. Docosahexaenoate (22:6n-3) seems to be the active component.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2006 Volume:55 | Number:1

Harvested from:

CDK

Metadata only:

false