Hypercapnia attenuates hypoxic pulmonary hypertension by inhibiting lung radical injury

Title:

Hypercapnia attenuates hypoxic pulmonary hypertension by inhibiting lung radical injury

Creator:

Milan Chovanec, Jana Novotná, Jiří Wilhelm, Václav Hampl, Martin Vízek, and Jan Herget

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:02afc7c9-01ab-4d13-973a-1a35be5b1a03
uuid:02afc7c9-01ab-4d13-973a-1a35be5b1a03

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, plicní hypertenze, physiology, pulmonary hypertension, chronická hypoxie, chronická hyperkapnie, hypoxické poranění plic, chronic hypoxia, chronic hypercapnia, hypoxic lung injury, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Chronic lung hypoxia results in hypoxic pulmonary hypertension. Concomitant chronic hypercapnia partly inhibits the effect of hypoxia on pulmonary vasculature. Adult male rats exposed to 3 weeks hypoxia (Fi02=0.1) combined with hypercapnia (FiC02=0.04-0.05) had lower pulmonary arterial blood pressure, increased weight of the right heart ventricle, and less pronounced structural remodeling of the peripheral pulmonary arteries compared with rats exposed only to chronic hypoxia (Fi02=0.1). According to our hypothesis, hypoxic pulmonary hypertension is triggered by hypoxic injury to the walls of the peripheral pulmonary arteries. Hypercapnia inhibits release of both oxygen radicals and nitric oxide at the beginning of exposure to the hypoxic environment. The plasma concentration of nitrotyrosine, the marker of peroxynitrite activity, is lower in hypoxic rats exposed to hypercapnia than in those exposed to hypoxia alone. Hypercapnia blunts hypoxia-induced collagenolysis in the walls of prealveolar pulmonary arteries. We conclude that hypercapnia inhibits the development of hypoxic pulmonary hypertension by the inhibition of radical injury to the walls of peripheral pulmonary arteries., M. Chovanec ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:Suppl 2

Harvested from:

CDK

Metadata only:

false