Does aliskiren protect the kidney following ischemia reperfusion injury?

Title:

Does aliskiren protect the kidney following ischemia reperfusion injury?

Creator:

Hammad, F. T., Al-Salam, S., and Lubbad, L.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:01d0d405-eb2d-4a4f-b072-a70c7b677b3f
uuid:01d0d405-eb2d-4a4f-b072-a70c7b677b3f

Subject:

Fyziologie člověka a srovnávací fyziologie, ischemie, ischemia, ischemia-reperfusion injury, aliskiren, renal function, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

The effect of blocking the first and rate-limiting step in renin-angiotensin cascade on the renal function in ischemia reperfusion injury has not been previously in vestigated. We investigated the effect of aliskiren, the first approved direct oral renin inhibitor, on the alterations in renal functional parameters in this condition. Wistar rats underwent left renal ischemia for 40 min. Group-1 received normal saline whereas Group-2 received aliskiren (30 mg/kg/day) by gavage for 6 days commencing one day before IRI. The hemodynamic an d tubular functions and gene expression of neutrophil gelatinase-associated lipocalin (NGAL) and plasminogen activating inhibitor (PAI-1) in the right and left kidneys were measured five days following the IRI. Comparing Group-1 and Group-2, the left renal blood flow was significantly higher in Group-2 (1.28±0.36 vs. 0.39±0.05, P=0.007). Left kidney glomerular filtration rate was also higher in Group-2 but did not reach statistical signif icance (0.18±0.05 vs. 0.10±0.02, P=0.07). The left renal FE Na was significantly lower in Group-2 (29.9±6.4 vs. 49.7±7.8, P=0.03). Aliskiren also caused a significant decrease in the gene expression of both NGAL and PAI-1 in the left ischemic kidney. In conclusions, the administration of aliskiren before and after IRI appears to have ameliorated the IRI effect on the total renal artery blood flow, and fractional excretion of sodium and gene expression of both NGAL and PAI-1 indicating a renoprotective effects in IRI., F. T. Hammad, S. Al-Salam, L. Lubbad., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2013 Volume:62 | Number:6

Harvested from:

CDK

Metadata only:

false