The aim was to investigate: changes of inflammatory, stress and
cardiac response in patients undergoing open heart surgeries up
to five days after the procedure; the association between
inflammatory, stress and cardiac response and whether changes
in a certain marker can predict short-term patient outcome.
Ninety patients were divided into three groups, 30 participants
each (on-pump, off-pump revascularization and valve
replacement group). The following markers were measured:
complete blood count, CRP, IL-6, IL-10, leptin, resistin, monocyte
chemoattractant protein-1 (MCP-1), cortisol, CK and hsTnT in
5 points. Resistin increased in all three groups. Lower IL-10 levels
were found after the surgery and higher levels of leptin and MCP1 in the off-pump than in the on-pump group. Off-pump group
had higher values of IL-6, IL-10, leptin, resistin and MCP-1 and
lower levels of CK and hsTnT 24 after surgery than the on-pump
group. We found significant correlation between MCP-1 and
resistin. The difference between resistin at time points 2 and 3
significantly predicted transfusion needs; while the difference
between CRP and resistin before and at the end of the surgery
together with the difference between leukocytes at the end and
24 hours after the surgery predicted the use of inotropic
agents/vasopressors. Cardiac surgeries cause an increase of
inflammatory, stress and cardiac markers. Only resistin correlated
with MCP-1 which confirms the link between resistin secreted
form infiltrated macrophages and enhanced release of MCP-1.