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2. Interaction between glycine and glutamate in the development of spontaneous motility in chick embryos
- Creator:
- Sedláček, J.
- Type:
- article, model:article, and TEXT
- Subject:
- chick embryo, spontaneous motility, glycine, glutamate, and NMDA receptor
- Language:
- English
- Description:
- In this study we investigated whether also glycine fullfils the function as co-activator in glutamatergic activation of NMDA receptors in the neuronal apparatus of spontaneous motility in chick embryos.The successive application of glycine (5 or 10 mg/kg egg weight (e.w.) and glutamate (15 mg/kg e.w.) in a 10 min interval significantly increased the activation of spontaneous motility of 17-day-old chick embryos in comparison with the effect of glutamate alone. This effect did not depend on the order of application of the drugs. In 13-day-old embryos, glycine was ineffective in both doses. It is concluded from these results that the modulatory effect of glycine is evidently a later developmental acquisition (after day 15 of incubation) in the embryogenesis of NMDA-ergic activation of spontaneous motility in chick embryos similarly as glycinergic inhibition.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
3. Sensitivity of the generator of spontaneous motility in chick embryos to the acute and chronic administration of MPTP
- Creator:
- Sedláček, J.
- Type:
- article, model:article, and TEXT
- Subject:
- chick embryo, spontaneous motility, MPTP, nialamide, and MAO
- Language:
- English
- Description:
- The acute and chronic effect of l-methyl-4-plicnyl-l,2,3,6- tetrahydropyridine (MPTP) on spontaneous motor activity and its development was studied in chick embryos. 1. From the 13th day of incubation, the acute effect of MPTP (30 mg/kg e.w., up to 60 min after administration) consisted in significant depression of spontaneous motility. From the 17th day, the effect of MPTP in supraspinal compartments of the CNS also began to participate in this depression. 2. Flic subacute effect of MPTP (up to 24 h after a single dose) was lethal for 11-day-old embryos. Conversely, in older embryos resting motility partly recovered, with signs of an inverse correlation to the embryo’s age. The final effect, however, consisted in absolute failure of the hatching process. 3. The chronic effect of MPTP (3.57 mg/kg e.w./24 h, from the 4th to the 16th day of incubation) led to a developmental reduction of spontaneous motor activity, chiefly from the 8th to 12th day of incubation. 4. The interaction of nialamide (25 mg/kg e.w.), a blocker of monoaminooxidasc produced disparate results with the effect of MPTP in young and old embryos.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public