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2. Early rehabilitation model shows positive effects on neural degeneration and recovery from neuromotor deficits following traumatic brain injury
- Creator:
- Marcela Lippert-Grüner, Maegele, M., Jaroslav Pokorný, Angelov, D. N., Olga Švestková, Michal Wittner, and Stanislav Trojan
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Patologie. Klinická medicína, neurorehabilitace, poranění mozku, léčebná rehabilitace, neurorehabilitation, brain injuries, therapeutic rehabilitation, motor dysfunction, neural loss, 14, and 616
- Language:
- English
- Description:
- This study used an experimental early rehabilitation model combining an enriched environment, multisensory (visual, acoustic and olfactory) stimulation and motor training after traumatic brain injury (via fluid-percussion model) to simulate early multisensory rehabilitation. This therapy will be used by brain injured patients to improve neural plasticity and to restore brain integration functions. Motor dysfunction was evaluated using a composite neuroscore test. Direct structural effects of traumatic brain injury were examined using Fluoro-Jade staining, which allows identification of degenerating neural cell bodies and processes. Animals in the rehabilitation model group performed significantly better when tested for neuromotor function than the animals in standard housing in the 7-day and 15-day interval after injury (7d: p=0.005; 15d: p<0.05). Statistical analysis revealed significantly lower numbers of Fluoro-Jade positive cells (degenerating neurons) in the rehabilitation model group (n=5: mean 13.4) compared to the standard housing group (n=6: mean 123.8) (p<0.005). It appears that the housing of animals in the rehabilitation model led to a clear functional increase in neuromotor functions and to reduced neural loss compared with the animal group in standard housing., M. Lippert-Grüner. M. Maegele, J. Pokorný, D. N. Angelov, O. Švestková, M. Wittner, S. Trojan., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
3. Long-term effects of enriched environment on neurofunctional outcome and CNS lesion volume after traumatic brain injury in rats
- Creator:
- Maegele, M., Braun, M., Wafaisade, A., Schäfer, N., Marcela Lippert-Grüner, Kreipke, C., Rafols, J., Schäfer, U., Angelov, D. N., and Stuermer, E. K.
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, poranění mozku, brain injuries, traumatic brain injury, enriched environment, controlled cortical impact, neurobehavioral, functional recovery, 14, and 612
- Language:
- English
- Description:
- To determine whether the exposure to long term enriched environment (EE) would result in a continuous improvement of neurological recovery and ameliora te the loss of brain tissue after traumatic brain injury (TBI) vs. standard housing (SH). Male Sprague-Dawley rats (300-350 g, n=28) underwent lateral fluid percussion brain injury or SHAM operation. One TBI group was held under complex EE for 90 days, the other under SH. Neuromotor and sensorimotor dysfunction and recovery were assessed after injury and at days 7, 15, and 90 via Composite Neuroscore (NS), RotaRod test, and Barnes Circular Maze (BCM). Cortical tissue loss was assessed using serial brain sections. After day 7 EE animals showed similar latencies and errors as SHAM in the BCM. SH animals performed notably worse with differences still significant on day 90 (p<0.001). RotaRod test and NS revealed superior results for EE animals after day 7. The mean cortical volume was significantly higher in EE vs. SH animals (p=0.003). In summary, EE animals after lateral fluid percussion (LFP) brain injury performed sign ificantly better than SH animals after 90 days of recovery. The window of opportunity may be wide and also lends further credibility to the importance of long term interventions in patients suffering from TBI., M. Maegele, M. Braun, A. Wafaisade, N. Schäfer, M. Lippert-Gruener, C. Kreipke, J. Rafols, U. Schäfer, D. N. Angelov, E. K. Stuermer., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public