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26. Synthesis of water-soluble star polymers based on cyclodextrins

Creator:
Kotrchová, L and Tomáš Etrych
Format:
print, bez média, and svazek
Type:
model:article and TEXT
Subject:
polymery, léky, polymers, drugs, Drug delivery system, HPMA copolymers, RAFT polymerization, Star polymers, 14, and 612
Language:
English
Description:
Novel star polymers based on the water-soluble N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer and cyclodextrin were synthesized and the physico-chemical behavior of these precursors was studied. Semitelechelic HPMA copolymers were grafted onto the cyclodextrin core, thus forming star-like structure. Both prepared systems were designed as possible polymer carriers for the controlled release of cytostatic drugs, which after the drug release and degradation will be eliminated from the organism. Two synthesis approaches were used to obtain similar polymer carriers with different degradation rates. All the polymers were prepared by reversible additionfragmentation chain-transfer polymerization, which guarantees low dispersity of the prepared systems., L. Kotrchová, T. Etrych., and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

30. Z dějin výroby českého penicilinu /

Creator:
Koštíř, Josef V.
Subject:
Koštíř, Josef V., Balaš, František,, Ruzycka, Leopold,, Kondakov, Ivan L.,, Tomíček, Oldřich,, Pelnář, Josef,, Šilink, Karel,, Pospíšil, Václav,, Heyrovský, Jaroslav,, Buchar, Eugen,, Fragner, Jiří,, Čupík, Jaroslav,, průmysl farmaceutický, farmacie, léčiva, léky, výroba léčiv, vzpomínky, chemici, učitelé, výzkumy farmaceutické, biochemie, Československo 1918-1992, and lékárenství
Language:
Czech
Rights:
unknown