In this article, the author 1) defines the scope of attitudes towards Eastern wisdom in European humanities from ancient times up to the present (Plotinos, Schopenhauer, Eliade, etc.), 2) characterizes the essence of the basic barriers which block the instrumental employment of the above-mentioned texts in humanistic research, 3) points out model cases of explicit (Schopenhauer) and implicit (Heidegger) openness of the European way of thinking towards Eastern wisdom, 4) reveals the following epistemological symptoms of the essential part of source texts of Eastern wisdom: a) focus on the suppositional field (always differentiating) of semiosis or the sign syntagmas, b) experiential wholeness, c) eudemonic character and d) radical assumptions.