This paper reports the processes by which a single-phase 3-D CFD model of hydrodynamics in a 17-km-long dam reservoir was developed, verified and tested. A simplified VOF model of flow was elaborated to determine the effect of wind on hydrodynamics in the lake. A hexahedral mesh with over 17 million elements and a k-ω SST turbulence model were defined for single-phase simulations in steady-state conditions. The model was verified on the basis of the extensive flow measurements (StreamPro ADCP, USA). Excellent agreement (average error of less than 10%) between computed and measured velocity profiles was found. The simulation results proved a strong effect of wind on hydrodynamics in the lake, especially on the development of the water circulation pattern in the lacustrine zone.