Adiposis is reputed as a twin disease of type 2 diabetes and
greatly harmful to human health. In order to understand the
molecular mechanisms of adiposis, the changes of physiological,
pathological, epigenetic and correlative gene expression were
investigated during the adiposis development of C57BL/6J mice
induced by long time (9 months) high-fat and high-sucrose diet
(HFSD) sustainably. The results showed that mRNA transcription
level of the Leptin, Glut4 and Glut2 genes have been obviously
changed, which exhibit a negative correlation with methylation
on their promoter DNA. The results also revealed that HFSD
induced higher level of DNA methyltransferase 1 (DNMT1) in fat
tissue might play important role in regulating the changes of
methylation pattern on Glut4 and Leptin genes, and which might
be one of the molecular mechanisms for the adiposis
development.