Growth factors are powerful molecules that regulate cellular growth, proliferation, healing, and cellular differentiation. A delivery matrix that incorporates growth factors with high loading efficiencies, controls their release, and maintains bioactivity would be a powerful tool for regenerative medicine. Alginate has several unique properties that make it an excellent platform for the delivery of proteins. Mild gelling conditions can minimize the risk of protein denaturation; moreover, alginate can serve as protection from degradation until protein release. Various modifications have been proposed to tune alginate binding and release proteins, simultaneously adjusting alginate degradability, mechanical stiffness, swelling, gelation properties and cell affinity. The primary objective of this article is to review the literature related to recent advances in the application of alginate matrices in protein delivery in regenerative medicine. A special emphasis is put on the relevance of delivery of growth factors and chemokine., E. Wawrzyńska, D. Kubies., and Obsahuje bibliografii
Lasers found their way into many applications. One of them is utilisation of lasersin material research. This paper isfocused on laser method of thin layers preparation and on hybrid laser technologies combining laser with magnetron, with radiofrequency discharge, and ion bombardment of layers. Hybrid systemssignificantly widen the field of laser deposition a quality of prepared coatings. Basic principles and applications in optoelectronics and v biomedicine are discussed. and Lasery jsou aplikovány v řadě činností, jednou ze zajímavých oblastí je použití laserů v materiálovém výzkumu. Článek pojednává o laserové metodě přípravy tenkých vrstev a o hybridních laserových technologiích kombinujících laser s magnetronem, sradiofrekvenčními výboji a siontovým bombardováním vrstev. Hybridní systémy značně rozšiřují oblasti laserových depozic a možnosti zvýšení kvality vytvářených pokrytí. Jsou vysvětleny principy a vyzdviženy některé aplikace v optoelektronice a v biomedicíně.