Hospitalized patients in internal medicine have an increased risk of low physical reserve which further declines during the hospital stay. The diagnosis requires bed-side testing of functional domains or more complex investigations of the muscle mass. Clinically useful biomarkers of functional status are needed, thus we aimed to explore the potential of microRNAs. Among hospitalized patients, we recorded the basic demographics, anthropometrics, nutritional status, and physical function domains: hand-grip strength (HGS, abnormal values M<30 kg, W<20 kg), balance (<30 s), chair-stands speed (CHSS<0.5/s) and gait speed (GS<0.8 m/s). A panel of five micro-RNAs (miRNA 1, miRNA 133a, miRNA 133b, miRNA 29a, miRNA 29b) and basic blood biochemistry and vitamin D values were recorded. We enrolled 80 patients (M40, W40), with a mean age of 68.8± 8.4 years. Obesity was observed in 27.5 % and 30 %, low HGS and low CHSS in 65.0, 77.5 %, and 80, 90 % of men and women respectively. The median hospital stay was 6.5 days. MiRNA29a and miRNA29b have the strongest correlation with the triceps skinfold (miRNA 29b, r=0.377, p=0.0006) and CHSS (miRNA 29a, r=0.262, p=0.02). MiRNA 29a, miRNA 29b and 133a levels were significantly higher in patients with CHSS<0.5/s. Other anthropometric parameters, mobility domains, or vitamin D did not correlate. All miRNAs except of miRNA 1, could predict low CHSS (miRNA29b, AUROC=0.736 CI 0.56-0.91, p=0.01), particularly in patients with low HGS (miRNA 29b, AUROC=0.928 CI 0.83-0.98). Among hospitalized patients in internal medicine, low functional status was frequent. MicroRNAs were fair biomarkers of the antigravity domain, but not other domains. Larger studies with clinical endpoints are needed., Petra Vrbová, Simona Valášková, Andrea Gažová, Juraj Smaha, Martin Kužma, Ján Kyselovič, Juraj Payer, Tomáš Koller., and Obsahuje bibliografii
The Kanisheeteh bauxite deposit (NW Iran) is located on the Irano-Himalaya karst bauxite belt and was developed as stratiform horizon along the contact of the Permian and Triassic formations. Based on absolute weathering index (AWI), HREE were leached out, whereas LREE suffered both leaching and fixation during bauxitization. The non-CHARAC characteristic of Y/Ho ratios can be attributed to geochemically known phenomenon as the "tetrad effect". The simultaneous convex and concave curves of the tetrad effect were observed in the chondrite-normalized REE patterns of the bauxite ores. The correlation between the sizes of T4 and AWI% values revealed two separate populations. The first one is characterized by a wide variation in sizes of T4 and very narrow AWI% values, and is thought to be related to acidic zone of the profile. In contrast, the second one is marked by a narrow variation in sizes of T4 and wide variation in AWI% values, and is conceived to be affiliated to alkaline zone of the profile. In this research, the tetrad effect proved to be capable of clarifying the geochemical characteristics of the deposit and can be applied as a good geochemical index to investigate the prevailed paleo-conditions of depositional environments.