Článek popisuje konstrukci polovodičových detektorů jednotlivých fotonů a jejich použití při velmi přesných měřeních vzdáleností a přenosu přesného času v kosmických projektech. Detektory vyvinuté v posledních třiceti letech na Českém vysokém učení technickém v Praze úspěšně pracují v laboratořích po celém světě i na palubě pěti kosmických sond., The construction of single photon semiconductor detectors is described in this paper together with their applications for high precision laser ranging and for laser time transfer in space projects. Detectors developed at the Czech Technical University in Prague over the last three decades are successfully operated on board of 5 satellites and in many labs worldwide., Ivan Procházka, Josef Blažej., and Obsahuje seznam literatury
The aim of our study was to investigate adrenocortical function in the context of disease activity and inflammatory status in premenopausal RA females. Adrenal glucocorticoid and androgen responses to the 1 μg ACTH 1-24 test were investigated in 23 premenopausal RA and in 15 age- and BMI-matched healthy females. Twelve RA patients were on low-dose prednisone (<8.5 mg/day). Patients with DAS28>3.2 had lower (p<0.05) total plasma cortisol, 17-hydroxyprogesterone, dehydroepiandrosterone and androstenedione responses in the ACTH test compared to healthy controls. Patients with DAS28>3.2 had lower (p<0.05) dehydroepiandrosterone response in the ACTH test compared to patients with DAS28≤3.2. C-reactive protein (CRP), DAS28, and interleukin (IL)-6 negatively correlated with androstenedione response to ACTH 1-24. Responses of all measured adrenal steroids were lower (p<0.05) in patients on low-dose glucocorticoids compared to healthy controls. RA patients not treated with glucocorticoids had lower total cortisol response (p=0.038) but did not differ in free plasma cortisol in the ACTH test. The results indicate an association of increased disease activity with a decrease in adrenal androgen production in RA and normal cortisol bioavailability in patients not treated with glucocorticoids., R. Imrich, M. Vlcek, J. Kerlik, M. Vogeser, F. Kirchhoff, A. Penesova, Z. Radikova, J. Lukac, J. Rovensky., and Obsahuje bibliografii
Let $S=\lbrace x_1,\dots ,x_n\rbrace $ be a finite subset of a partially ordered set $P$. Let $f$ be an incidence function of $P$. Let $[f(x_i\wedge x_j)]$ denote the $n\times n$ matrix having $f$ evaluated at the meet $x_i\wedge x_j$ of $x_i$ and $x_j$ as its $i,j$-entry and $[f(x_i\vee x_j)]$ denote the $n\times n$ matrix having $f$ evaluated at the join $x_i\vee x_j$ of $x_i$ and $x_j$ as its $i,j$-entry. The set $S$ is said to be meet-closed if $x_i\wedge x_j\in S$ for all $1\le i,j\le n$. In this paper we get explicit combinatorial formulas for the determinants of matrices $[f(x_i\wedge x_j)]$ and $[f(x_i\vee x_j)]$ on any meet-closed set $S$. We also obtain necessary and sufficient conditions for the matrices $f(x_i\wedge x_j)]$ and $[f(x_i\vee x_j)]$ on any meet-closed set $S$ to be nonsingular. Finally, we give some number-theoretic applications.
Diabetes mellitus type 2 ranks among the strongest predictors of cardiovascular diseases (CVD) while the association of type 1 diabetes with CVD is more complex. We studied differences between type 1 and 2 diabetic women regarding association of cardiovascular risk factors with preclinical atherosclerosis expressed as intima-media thickness of common carotid (IMT CCA) and femoral arteries (IMT CFA) measured by high resolution ultrasound. Women with type 1 (n=203) and type 2 diabetes (n=123) were examined with regard to the presence of cardiovascular risk factors. In type 1 diabetic women strong association between IMT CCA and body mass index, waist circumference, and total body fat was found in contrast to type 2 diabetic women. In type 2 diabetic women strong association between IMT CCA and fasting glucose, glycated hemoglobin, and atherogenic index of plasma (log TG/HDL cholesterol) was observed in contrast to type 1 diabetic women. In type 1 diabetic women, IMT CFA was associated with body fat in contrast to type 2 diabetic women. Preclinical atherosclerosis in type 1 diabetic women was strongly associated with factors reflecting body fat and its distribution, while in type 2 diabetic women preclinical atherosclerosis was associated with markers reflecting glucose and lipid metabolic disorders., P. Piťhová, K. Štechová, J. Piťha, V. Lánská, M. Kvapil., and Obsahuje bibliografii
Cardiovascular disease is a major cause of morbidity and mortality in young adults with end-stage renal disease (ESRD), but its basis is still not well understood. We therefore evaluated the determinants of atherosclerosis in children with ESRD. A total of 37 children with ESRD (with 31 who had undergone transplantation) were examined and compared to a control group comprising 22 healthy children. The common carotid intimamedia thickness (CIMT) was measured by ultrasound as a marker of preclinical atherosclerosis. The association of CIMT with anthropometrical data, blood pressure, plasma lipid levels, and other biochemical parameters potentially related to cardiovascular disease was evaluated. Children with ESRD had significantly higher CIMT, blood pressure, and levels of lipoprotein (a), urea, creatinine, ferritin, homocysteine, and serum uric acid as well as significantly lower values of apolipoprotein A. The atherogenic index of plasma (log(triglycerides/HDL cholesterol)) was also higher in patients with ESRD; however, this difference reached only borderline significance. In addition, a negative correlation was found between CIMT and serum albumin and bilirubin in the ESRD group, and this correlation was independent of age and body mass index. In the control group, a significant positive correlation was observed between CIMT and ferritin levels. Factors other than traditional cardiovascular properties, such as the antioxidative capacity of circulating blood, may be of importance during the early stages of atherosclerosis in children with endstage renal disease., H. M. Dvořáková ... [et al.]., and Obsahuje seznam literatury