Determinants of premature atherosclerosis in children with end stage renal disease

Title:

Determinants of premature atherosclerosis in children with end stage renal disease

Creator:

Hana Dvořáková, Peter Szitányi, Dvořák, P., Janda, J., Tomáš Seeman, Zieg, J., Věra Lánská, Kotaška, K., and Jan Piťha

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:f60ae1e3-7e58-4867-8870-20bcfea5c538
uuid:f60ae1e3-7e58-4867-8870-20bcfea5c538

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, atherosclerosis, children, carotid intima-media thicknes, end-stage renal disease, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Cardiovascular disease is a major cause of morbidity and mortality in young adults with end-stage renal disease (ESRD), but its basis is still not well understood. We therefore evaluated the determinants of atherosclerosis in children with ESRD. A total of 37 children with ESRD (with 31 who had undergone transplantation) were examined and compared to a control group comprising 22 healthy children. The common carotid intimamedia thickness (CIMT) was measured by ultrasound as a marker of preclinical atherosclerosis. The association of CIMT with anthropometrical data, blood pressure, plasma lipid levels, and other biochemical parameters potentially related to cardiovascular disease was evaluated. Children with ESRD had significantly higher CIMT, blood pressure, and levels of lipoprotein (a), urea, creatinine, ferritin, homocysteine, and serum uric acid as well as significantly lower values of apolipoprotein A. The atherogenic index of plasma (log(triglycerides/HDL cholesterol)) was also higher in patients with ESRD; however, this difference reached only borderline significance. In addition, a negative correlation was found between CIMT and serum albumin and bilirubin in the ESRD group, and this correlation was independent of age and body mass index. In the control group, a significant positive correlation was observed between CIMT and ferritin levels. Factors other than traditional cardiovascular properties, such as the antioxidative capacity of circulating blood, may be of importance during the early stages of atherosclerosis in children with endstage renal disease., H. M. Dvořáková ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2012 Volume:61 | Number:1

Harvested from:

CDK

Metadata only:

false