Variable rate technology (VRT) in nutrient management has been developed in order to apply crop inputs according to the required amount of fertilizers. Meteorological conditions rarely differ within one field; however, differences in soil conditions responding to precipitation or evaporation results within field variations. These variations in soil properties such as moisture content, evapotranspiration ability, etc. requires site-specific treatments for the produced crops. There is an ongoing debate among experts on how to define management zones as well as how to define the required amount of fertilizers for phosphorus and nitrogen replenishment for winter wheat (Triticum aestivum L.) production. For management zone delineation, vegetation based or soil based data collection is applied, where various sensor technology or remote sensing is in help for the farmers. and The objective of the study reported in this paper was to investigate the effect of soil moisture data derived from Sentinel-2 satellite images moisture index and variable rate phosphorus and nitrogen fertilizer by means of variable rate application (VRA) in winter wheat in Mezőföld, Hungary. Satellite based moisture index variance at the time of sowing has been derived, calculated and later used for data comparison. Data for selected points showed strong correlation (R2 = 0.8056; n = 6) between moisture index and yield, however generally for the whole field correlation does not appear. Vegetation monitoring has been carried out by means of NDVI data calculation. On the field level, as indicated earlier neither moisture index values at sowing nor vegetation index data was sufficient to determine yield. Winter wheat production based on VRA treatment resulted significant increase in harvested crop: 5.07 t/h in 2013 compared to 8.9 t/ha in 2018. Uniformly managed (control) areas provided similar yield as VRA treated areas (8.82 and 8.9 t/ha, respectively); however, the input fertilizer was reduced by 108 kg/ha N and increased by 37 kg/ha P.