In this paper we consider the nonlinear difference equation with several delays (axn+1 + bxn) k − (cxn) k + ∑m i=1 pi(n)x k n−σi = 0 where a, b, c ∈ (0, ∞), k = q/r, q, r are positive odd integers, m, σi are positive integers, {pi(n)}, i = 1, 2, . . . , m, is a real sequence with pi(n) ≥ 0 for all large n, and lim inf n→∞ pi(n) = pi < ∞, i = 1, 2, . . . , m. Some sufficient conditions for the oscillation of all solutions of the above equation are obtained.