Acenocoumarol is a vitamin K antagonist that is used for the treatment of acquired and congenital, both arterial and venous, thrombotic diseases. Its use is complicated by the narrow therapeutic range. Bleeding following oral anticoagulation, despite rare, remains the major complication. Most cases of hemorrhagic episodes usually require short hospitalization and transfusion, while surgical drainage of the hematoma is not recommended. However, in cases that conservative treatment isn’t successful, surgical intervention remains an option. We present a case of severe spontaneous bleeding of the rectus abdominis muscle which was successfully managed surgically., Orestis Ioannidis, George Paraskevas, Anastasios Kotronis, Stavros Chatzopoulos, Athina Konstantara, Nikolaos Papadimitriou, Apostolos Makrantonakis, Emmanouil Kakoutis, and Literatura 15